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Cannabidiol (CBD) is a naturally occurring, non-psychotropic cannabinoid of the hemp plant <i>Cannabis sativa</i> L. and has been known to induce several physiological and pharmacological effects. While CBD is approved as a medicinal product subject to prescription, it is also widely sold over the c … THC and CBD both come from cannabis, but they have different effects on the body and mind, and they aren’t always legal. Learn more. The cannabis-derived chemical is non-psychoactive, and – while federally illegal – has been hailed as a cure for disease<br>

Conversion of Cannabidiol (CBD) into Psychotropic Cannabinoids Including Tetrahydrocannabinol (THC): A Controversy in the Scientific Literature

Cannabidiol (CBD) is a naturally occurring, non-psychotropic cannabinoid of the hemp plant Cannabis sativa L. and has been known to induce several physiological and pharmacological effects. While CBD is approved as a medicinal product subject to prescription, it is also widely sold over the counter (OTC) in the form of food supplements, cosmetics and electronic cigarette liquids. However, regulatory difficulties arise from its origin being a narcotic plant or its status as an unapproved novel food ingredient. Regarding the consumer safety of these OTC products, the question whether or not CBD might be degraded into psychotropic cannabinoids, most prominently tetrahydrocannabinol (THC), under in vivo conditions initiated an ongoing scientific debate. This feature review aims to summarize the current knowledge of CBD degradation processes, specifically the results of in vitro and in vivo studies. Additionally, the literature on psychotropic effects of cannabinoids was carefully studied with a focus on the degradants and metabolites of CBD, but data were found to be sparse. While the literature is contradictory, most studies suggest that CBD is not converted to psychotropic THC under in vivo conditions. Nevertheless, it is certain that CBD degrades to psychotropic products in acidic environments. Hence, the storage stability of commercial formulations requires more attention in the future.

Keywords: Cannabis sativa; cannabidiol; degradation; psychotropic effects; tetrahydrocannabinol.

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Chemical structures of ( a…

Chemical structures of ( a ) cannabinol (CBN) including the numbering system, (…

Chemical structures of (a) cannabinol (CBN) including the numbering system, (b) Δ 9 -tetrahydrocannabinol (Δ 9 -THC) and (c) cannabidiol (CBD).

Google trends analysis for cannabidiol…

Google trends analysis for cannabidiol (CBD) (Data source: Google Trends [23]).

Chemical structures of ( a…

Chemical structures of ( a ) hexahydrocannabinol (HHC), ( b ) cannabigerol (CBG)…

Chemical structures of (a) hexahydrocannabinol (HHC), (b) cannabigerol (CBG) and (c) cannabichromene (CBC).

Overview of various chemical conversions…

Overview of various chemical conversions of cannabidiol (CBD) to different conversion products and…

Overview of various chemical conversions of cannabidiol (CBD) to different conversion products and the respective conditions, which are reported in the literature.

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Chemical structures of ( a…

Chemical structures of ( a ) cannabidiolic acid (CBDA) and ( b )…

Chemical structures of (a) cannabidiolic acid (CBDA) and (b) Δ 9 -tetrahydrocannabinolic acid (Δ 9 -THCA).

CBD vs. THC: What’s the Difference?

You’re probably hearing a lot about cannabis and marijuana products as they become legal in more and more states. Two natural compounds are getting the most attention: CBD and THC.

Cannabis is a plant that makes a thick substance full of compounds called cannabinoids. There are more than 100 of these chemicals in cannabis. They cause drug-like reactions in your body.

CBD (cannabidiol) and THC (tetrahydrocannabinol) are the most common cannabinoids found in cannabis products.

THC and CBD are in both marijuana and hemp. Marijuana contains much more THC than hemp, while hemp has a lot of CBD.

Chemical Structure

CBD and THC have the same chemical formula — 21 carbon atoms, 30 hydrogen atoms, and two oxygen atoms. The difference lies in the way the atoms are arranged. That gives CBD and THC different chemical properties, and they affect your body differently.

Both CBD and THC work with receptors that release neurotransmitters in your brain. They can affect things like pain, mood, sleep, and memory.

How CBD and THC Affect the Body

THC is the main psychoactive compound in marijuana. It’s what makes people feel “high.”

We have two types of cannabinoid receptors in our bodies. THC binds with receptors — mostly in the brain — that control pain, mood, and other feelings. That’s why THC can make you feel euphoric and give you that so-called high.

CBD doesn’t cause that high. Instead, it’s thought to work with other elements in the body linked to feelings of well-being.

Medical Benefits

People take CBD products to help with everything from arthritis and Crohn’s disease to diabetes and multiple sclerosis. Some say it helps with anxiety, insomnia, and chronic pain. So far, there’s little evidence that CBD helps with any of these.

The FDA has approved one CBD-based drug. Epidiolex is a treatment for several severe forms of rare childhood epilepsy.

CBD is a hot topic for researchers. The National Institutes of Health clinical trials database shows more than 160 trials involving CBD that are either active or recruiting.

Some states authorize the use of THC as part of medical marijuana, THC may help ease things like:

Side Effects

  • Problems with concentration
  • Dizziness
  • Vomiting
  • Drowsiness
  • Balance
  • Memory loss

Side effects from CBD can include:

  • Nausea
  • Upset stomach
  • Tiredness
  • Lightheadedness
  • Crankiness
  • Drowsiness

CBD can also change the way some medicines work. Talk with your doctor about it.

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What’s Legal?

Laws are changing all the time on cannabis. Many states allow medical marijuana, containing THC, for several uses, but it is still illegal under federal law. Some states have made recreational marijuana with THC legal for personal use. But it’s also illegal under U.S. law.

As part of the Farm Bill in December 2018, Congress legalized hemp. But there are still rules about where and how you can sell products that contain CBD. You can’t sell some across state lines, for example. All CBD products are illegal if they’re sold with the promise of medical benefits.

Check your state’s laws before buying products with CBD or THC.

Show Sources

National Cancer Institute: “Cannabis and Cannabinoids (PDQ) — Patient Version.”

Dialogues in Clinical Neuroscience: “Cannabis, cannabinoids, and health.”

Echo Connection: “4 Differences Between CBD and THC,” “What Are the Differences Between CBD and THC?”

American Council on Science and Health: “CBD And THC – The Only Difference Is One Chemical Bond.”

Harvard Health Publishing: “Answers to the top questions about cannabis extract,” “Medical marijuana.”

FDA: “FDA approves first drug comprised of an active ingredient derived from marijuana to treat rare, severe forms of epilepsy.”

U.S. National Library of Medicine ClinicalTrials.gov: “CBD.”

UW Health: “Do You Vomit When You Smoke Pot? Here’s Why.”

Alcohol and Drug Foundation: “Medical cannabis.”

National Center for Complementary and Integrative Health: “Marijuana and Cannabinoids.”

What is CBD? The ‘miracle’ cannabis compound that doesn’t get you high

In early May, a federal court declined to protect cannabidiol (CBD), a chemical produced by the cannabis plant, from federal law enforcement, despite widespread belief in its medical value.

The ruling was contrary to existing evidence, which suggests the chemical is safe and could have multiple important uses as medicine. Many cannabis advocates consider it a miracle medicine, capable of relieving conditions as disparate as depression, arthritis and diabetes.

The perception of its widespread medical benefits have made the chemical a rallying cry for legalization advocates.

The first thing to know about CBD is that it is not psychoactive; it doesn’t get people high. The primary psychoactive ingredient in marijuana is tetrahydrocannabinol (THC). But THC is only one of the scores of chemicals – known as cannabinoids – produced by the cannabis plant.

So far, CBD is the most promising compound from both a marketing and a medical perspective. Many users believe it helps them relax, despite it not being psychoactive, and some believe regular doses help stave off Alzheimer’s and heart disease.

While studies have shown CBD to have anti-inflammatory, anti-pain and anti-psychotic properties, it has seen only minimal testing in human clinical trials, where scientists determine what a drug does, how much patients should take, its side effects and so on.

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Despite the government ruling, CBD is widely available over the counter in dispensaries in states where marijuana is legal.

CBD first came to public attention in a 2013 CNN documentary called Weed. The piece, reported by Dr Sanjay Gupta, featured a little girl in Colorado named Charlotte, who had a rare life-threatening form of epilepsy called Dravet syndrome.

At age five, Charlotte suffered 300 grand mal seizures a week, and was constantly on the brink of a medical emergency. Through online research, Charlotte’s desperate parents heard of treating Dravet with CBD. It was controversial to pursue medical marijuana for such a young patient, but when they gave Charlotte oil extracted from high-CBD cannabis, her seizures stopped almost completely. In honor of her progress, high-CBD cannabis is sometimes known as Charlotte’s Web.

CBD has been sought for its healing properties. Illustration: George Wylesol

After Charlotte’s story got out, hundreds of families relocated to Colorado where they could procure CBD for their children, though not all experienced such life-changing results. Instead of moving, other families obtained CBD oil through the illegal distribution networks.

In late June, the US Food and Drug Administration could approve the Epidiolex, a pharmaceuticalized form of CBD for several severe pediatric seizure disorders. According to data recently published in the New England Journal of Medicine, the drug can reduce seizures by more than 40%. If Epidiolex wins approval it would be the first time the agency approves a drug derived from the marijuana plant. (The FDA has approved synthetic THC to treat chemotherapy-related nausea.)

Epidiolex was developed by the London-based GW Pharmaceuticals, which grows cannabis on tightly controlled farms in the UK. It embarked on the Epidiolex project in 2013, as anecdotes of CBD’s value as an epilepsy drug began emerging from the US.

While parents treating their children with CBD had to proceed based on trial and error, like a folk medicine, they also had to wonder whether dispensary purchased CBD was professionally manufactured and contained what the package said it did. GW brought a scientific understanding and pharmaceutical grade manufacturing to this promising compound.

Fortunately, like THC, CBD appears to be well tolerated; as far as I can tell, there are no recorded incidents of fatal CBD overdoses.

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