CBD Oil Cause Dry Mouth


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Do CBD supplements leave an unpleasant dryness in your mouth? Here’s why it happens and what you can do about this constant dry and pasty mouth sensation. Ever wondered why CBD causes the dry mouth effect? This article explains why it happens and how to deal with dry mouth after taking CBD oil. You have probably heard of the benefits surrounding CBD, but what are the potential side effects you ought to be aware of?

Can CBD Cause Dry Mouth?

Do CBD supplements leave an unpleasant dryness in your mouth? Here’s why it happens and what you can do about this constant dry and pasty mouth sensation.

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From pills to gummies, CBD is gaining popularity due to its seemingly endless health benefits. Though CBD products are considered safe for human consumption, it comes with a few side effects.

Whether you consume CBD for medicinal or recreational purposes, these products often result in a dry mouth or what’s known as cottonmouth. Here’s why it happens and what you can do about it.

Table of Contents

Why Does CBD Cause Dry Mouth (CottonMouth)?

Though CBD causes minimal side effects, it’s impossible to disregard the fact that this cannabis product is responsible for the most common adverse effect – dry mouth.

For some, dry mouth can last for a couple of hours or until the effects of the CBD wear off.

Cannabis Affects the Salivary Glands

The dry sensation occurs when the CBD products inhibit the secretion of saliva in the mouth.

The CBD oil alters how the salivary glands respond and prevent them from secreting the regularly required amount of saliva in the mouth. This results in irritability and pain on the tongue and mouth, making you feel more thirsty.

Presence of Impurities

Impure CBD can contain toxic byproducts, causing severe health hazards. These impurities can irritate the mouth and lungs, leading to cottonmouth or irritation of the mouth and throat.

If you’re experiencing severe dry mouth, itchiness, or swelling of your mouth and throat — visit a doctor immediately; this is not a normal side effect of CBD.

Incorrect Dosage

Numerous food safety agencies have advised users not to exceed 80 – 90 mg of CBD daily for healthy adults. Exceeding this can cause side effects like cottonmouth.


Different CBD forms result in various side effects. For instance, smoking or dabbing CBD can damage your lungs and cause sore throat, severe coughing, and dryness in the mouth for some users.

Using Sprays & Tinctures

CBD-infused sprays and tinctures are applied directly into the mouth and quickly reach the salivary glands, causing dry mouth.

Using these CBD forms more frequently can cause an unpleasant stinging sensation and burns, in some cases.

Vape Inhalation

Vaping CBD is much safer than smoking as it produces less toxic byproducts. However, the thinning agents and flavoring additives used in vaping oil pose serious health hazards.

When vaped, these harmful additives may result in cottonmouth, severe cough, and lung injuries for some users.

What Can I Do About Dry Mouth From CBD?

Experiencing dryness in the mouth and throat after ingesting CBD is quite common. It often doesn’t take much CBD consumption to induce this adverse effect. Heavy CBD users may experience a constant dry mouth effect, which can be highly annoying.

Preventing cottonmouth is better than having to combat it when it happens. Here are a few remedies that can help de-escalate this unpleasant experience before it escalates.

1. Stay Hydrated

The best way to reduce or prevent the offset of cottonmouth while using CBD oil is to consume plenty of water and keep yourself hydrated throughout the day. Also, drinking other hydrating liquids immediately before, during, and after consuming CBD can help mitigate this annoying issue to a certain extent. Drinking warm herbal teas can keep you hydrated and prevent an irritated or sore throat.

2. Increase Saliva Production

Using toothpaste and lozenges that promote saliva production can help mouth dryness. Sucking on hard candies or lollipops is also helpful. Taking demulcent cough drops will create a moist film coating on the mucous membranes and prevent dryness in the throat and mouth.

3. Chew Gum

Opting for CBD-infused chewing gum is one of the best and innovative ways to include this supplement in your diet. The CBD gets absorbed directly into the bloodstream through the capillaries present in your tongue. Most natural CBD gum supplements do not contain artificial ingredients and are flavored with peppermint essential oil and xylitol.

Another method to effectively cure cottonmouth is by chewing gums that contain xylitol. This natural sugar helps stimulate the salivary glands and increases the production of saliva in the mouth.

These CBD chewing gums are available in different potencies, so stick to the recommended dosage to avoid this effect.

4. Try Another Form of CBD

When using CBD, opt for topical or oral consumption instead of vape or smoke inhalation. Numerous CBD products are available that do not require vaping or smoking. This protects your lungs and prevents harmful components like carbon monoxide from infiltrating your bloodstream.

Ingesting CBD capsules, oils, and edibles is less harmful and prevent dryness in the mouth and sore throat. Also, CBD gels, lotions, balms, and creams can prevent CBD from causing the dry effect in the mouth, as it only acts on the site of application.

5. Eat Fruit

Fresh citrus fruits like orange, pineapple, or lemon can help eliminate dry mouth. Some individuals claim that drinking pineapple juice has helped. However, you can try different fruit juices to find out which one is effective for you.

Chewing on dry fruits, beef jerky, or sucking ice cubes will also help stimulate saliva production and keep your mouth well hydrated, reducing this side effect to a great extent.

Other Side Effects of CBD

Though CBD has a good tolerance and side effect profile, it’s not free from adverse effects. Generally, CBD products are considered safe for oral consumption or topical application. In some cases, it can cause mild side effects.

Patients on medications such as blood thinners need to be careful as CBD can interact with different medicines and cause adverse reactions.

Here are some of the most common side effects of CBD.

Gastrointestinal Problems

Some users experience indigestion or diarrhea while consuming CBD.

This unfortunate symptom happens when the oil affects the gastrointestinal tract, leading to diarrhea. Such individuals need to monitor their medical history while using CBD.


Since CBD is an excellent treatment for insomnia, it’s no surprise that users experience sedation or drowsiness while taking CBD products. It’s advisable to adjust your schedule and try taking it before bed.

Low Blood Pressure

Consuming higher doses of CBD can lower blood pressure. This can be risky for individuals diagnosed with low blood pressure or those on medication for high blood pressure.

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When this happens, you may feel dizzy or lightheaded. Drink plenty of fluids and lie down to help stabilize blood pressure if this happens to you.

Avoid moving around too much. If you faint, you could seriously injure yourself or others.


Some users may feel nauseous while ingesting CBD products. This varies based on the amount of CBD you consume and how sensitive your body is to CBD oil.

Summary: Does CBD Cause Dry Mouth?

CBD can cause dry mouth but be it over-the-counter or prescribed, CBD supplements can cause adverse reactions if not used as recommended. Usually, the benefits and side effects of CBD are unique for each individual.

Adjusting your dose, chewing gum, eating fruit, and staying hydrated are just a few ways you can help or prevent cottonmouth.

As the body type of each individual is different, the cure won’t look the same for everyone. What works perfectly for one CBD user may not function the same for another. You need to consult your physician before you start consuming CBD supplements daily to minimize unwanted risks.

To avoid severe side effects from impure CBD, purchase your CBD supplements from a certified source. This is the only way you know your product is pure, potent, and will give you the benefits you’re after.

Can CBD Oil Cause Dry Mouth?

Do you regularly experience dry mouth after taking CBD? You’re not alone.

In fact, this effect is common for all cannabinoids, not only for CBD. But does it mean that cannabis users just have to accept it and go on with their supplementation?

Or is there a way to minimize the dry mouth effect after using CBD oils and vapes?

There are at least a few ways to help you cope with the cottonmouth.

It’s just so common that hardly anyone is questioning the mechanism at work.

Today, we explain why CBD gives you the dry mouth feeling and how to cope with it using some simple tricks.

Why Does CBD Cause Dry Mouth (Cottonmouth)

Several factors can cause dry mouth after taking CBD oil or any cannabis-based product. This section holds the answer to the “why” behind the cottonmouth effect.

Cannabinoids Affect Salivary Glands

Several studies point to cannabis use as the reason for having a dry mouth. A 1986 study on the effects of CBD noted that the side effects of oral CBD included dry mouth.

Since then, a few other studies have investigated this effect. Oral dryness even has a scientific name — xerostomia.

Perhaps the most relevant study on CBD-induced oral dryness comes from the researchers at the University of Buenos Aires, Argentina, in 2006. The authors found that cannabinoid receptors type 1 and 2 (CB1 and CB2) occur in the submandibular glands, which lie beneath the bottom of the mouth and are responsible for the secretion of 60-67% of the saliva (1).

The research team found that anandamide, which is one of the two major endocannabinoids produced by the body, binds with high affinity to these cannabinoid receptors and blocks the secretion of saliva.

Both THC and CBD interact with the cannabinoid receptors of the parasympathetic nervous system, so they’re likely to affect the receptors of the submandibular glands in a similar fashion.

CBD May Signal Your Brain to Slow Down Saliva Production

The said study also concluded that the role of the endocannabinoid system reaches beyond simply blocking signals at the submandibular glands themselves. The nervous signals are first created in the brain.

The researchers drew out a hypothesis that intravenous application of cannabinoids through the femoral vein not only blocked the saliva secretion in the submandibular gland but it may also have interacted with the CB1 and CB2 receptors in the brain itself. They proposed that the central nervous system helps to control saliva production at the glandular level.

Impurities in CBD Oil

Contaminated CBD oils can contain dangerous byproducts, causing serious health risks. These contaminants can cause irritation in the mouth and lungs, resulting in dry mouth or irritation of the oral tract.

If you’re experiencing severe discomfort caused by the dryness, itchiness, or swelling of your mouth and throat — seek medical attention immediately. This isn’t a normal side effect of CBD oil.

Too High a Dose

Agencies responsible for regulating food safety have advised users not to exceed a dose of 100 mg of CBD daily for healthy adults. Breaching this threshold can lead to side effects like dry mouth.

Smoking Cannabis

Different forms of CBD can produce various side effects. For example, smoking CBD flowers or dabbing CBD concentrates can irritate your mouth, throat, and lungs, causing coughing and dryness in the mouth for some individuals.

Using Sprays and Tinctures

Using sublingual forms of CBD, such as sprays or tinctures, causes the CBD to absorb through the mucous membrane in the mouth. From there, CBD can reach the cannabinoid receptors in your salivary gland, inhibiting saliva secretion and causing dry mouth.

Taking these forms of CBD more frequently can cause regular discomfort in the mouth and even an unpleasant stinging sensation in some cases.

Vaping CBD

Vaping CBD is considered safer than smoking because it produces fewer toxic byproducts such as carcinogens. However, the flavorings and thinning agents used in vape oils can cause serious health risks. Moreover, when you vape CBD, it also reaches your salivary glands, thus reducing saliva secretion in the mouth.

How to Cope with Dry Mouth from CBD?

As you can see, CBD and dry mouth come hand in hand, so it’s no wonder why people are seeking ways to cope with this side effect.

Worse yet, you don’t need to take much CBD in order to experience dryness in the mouth. For heavy CBD users, this side effect is their daily companion — and an annoying one, to be honest.

Preventing cottonmouth is better than having to fight it when it appears. Here are a few ways to help yourself cope and de-escalate this unpleasant sensation before it becomes a pain in the mouth.

1. Hydrate Yourself

The best method for preventing or reducing the offset of cottonmouth while using CBD oil is to drink a lot of water and take care of proper hydration throughout the day. Also, drinking other hydrating liquids such as electrolytes right before, during, and after taking CBD oil can help diminish this annoying problem to some extent. Drinking herbal teas and warm water is the best for hydration and easing sore throat.

2. Increase Saliva Production

Try using toothpaste, lozenges, or lollipops to combat mouth dryness by increasing saliva production. Sucking on lollipops or hard candies stimulates your salivary glands to produce more saliva and creates a moist film lining the mucous membranes and preventing dryness in the mouth and throat.

3. Chew Gum

Choosing CBD-infused chewing gum is one of the best ways to avoid dry mouth. The CBD gets absorbed right into the bloodstream through the capillaries located under the tongue. Most natural CBD gum supplements are sugar-free and don’t contain artificial ingredients such as sweeteners or aromas. They rather use peppermint essential oil and xylitol as flavorings.

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Another method to effectively cope with dry mouth is by chewing gums that contain xylitol. This natural sweetener helps activate salivary glands and pumps up the production of saliva in the mouth.

You can find CBD chewing gum in different potencies, so make sure to follow the recommended dosage to avoid cottonmouth.

4. Eat Fruit

Fresh citrus fruits, such as lemon, orange, or pineapple, can help you get rid of the dry mouth feeling. Chewing on dry fruits, ice cubes, or beef jerky will also help activate salivary glands and reduce this side effect to a great extent — especially if you keep yourself hydrated throughout the day.

5. Try Another Form of CBD

When taking CBD oil, it’s best to go with oral or topical forms if you want to avoid experiencing a dry mouth. There are a lot of CBD products that don’t require you to smoke or vape them. This not only protects your lungs but also prevents cottonmouth from occurring.

How Is Saliva Formed?

To elaborate on the subject of CBD and dry mouth, let’s take a look at how saliva is formed.

Saliva formation occurs at two stages.

First, certain cells known as acinar cells form a fluid that has a similar composition to plasma. This fluid then moves through the salivary ducts to enter the oral cavity, and once it succeeds, sodium chloride is removed from it, and potassium and bicarbonate are added.

This stage is known as the final hypotonic solution that is secreted in the salivary glands.

Saliva secretion is managed by the parasympathetic nervous system (PSNS). The PSNS often controls different metabolic processes linked to appetite, food intake, and anticipation of eating.

Salivary receptors are activated by impulses from the chorda tympani nerve. This essential nerve stems from the taste buds before traveling through the cluster of nerve cells located in the submandibular gland.

The chorda tympani nerve produces a compound called acetylcholine, which is one of the body’s main saliva-inducing substances and works directly on the receptors of the submandibular gland.

Another important factor involved in the formation of saliva is norepinephrine. This compound is produced by the preganglionic nerves and works directly on the myoepithelial cells that surround the acinar cells; this contact results in saliva secretion.

Other Side Effects of CBD

Although CBD is generally safe and well-tolerated, it also has some mild side effects. Patients on medications such as blood thinners should consult a doctor before buying CBD products because CBD can interact with different medicines and cause adverse effects.

Here are some of the most common negative reactions to CBD.


Since CBD is a decent sleep aid, it’s no wonder that people experience sedation or drowsiness, especially when taking CBD products in high doses. It’s recommended to adjust your schedule and try taking it in the evening or right before bed so that you can normally function throughout the day (2).

Changes in Appetite

CBD has a biphasic nature, meaning that it can produce different effects in the same individual depending on the conditions under which it is used. Some studies point to CBD as a mild appetite suppressant, while others have found that CBD can actually increase appetite. It’s best to monitor your body’s response to CBD, and if you notice any changes in your appetite, try to adjust the dosage so that it doesn’t cause such fluctuations (3).

Low Blood Pressure

A 2017 study found that a single dose of CBD can lower blood pressure in healthy individuals — both when at rest and when put under stressful situations. This side effect can be risky for people diagnosed with low blood pressure or those who take blood thinners as part of their medication (4).

When this side effect occurs, you may feel lightheaded or drowsy. Lie down and drink plenty of liquids to help stabilize blood pressure if CBD lowers it too much.

Avoid physical activity during that time. In case of fainting, you could injure yourself or other people around you.


Some users report indigestion or diarrhea after consuming CBD. This unfortunate side effect occurs when you take too much CBD oil, which can further irritate the gastrointestinal tract and trigger diarrhea. Studies have found that diarrhea occurs in people who take more than 300 mg of CBD oil at a time (5).

Key Takeaways on CBD and Dry Mouth

CBD can lead to dry mouth due to its interaction with cannabinoid receptors located in the salivary glands in your mouth.

When you don’t use CBD as recommended, these supplements can cause adverse reactions, such as dry mouth feeling. Usually, the more you take it, the more apparent this side effect will be.

Make sure that you use a clean CBD product, use chewing gum, eat fruit, and stay hydrated if you want to prevent or reduce the intensity of the dry mouth feeling.

Certain types of CBD, such as tinctures and vapes, can make this sensation even more annoying, so if that’s your case, we suggest that you switch to an oral or topical form.

Regardless of your choice, always check for the certificates of analysis for any CBD product out there. Doing so will help you confirm the product’s potency and purity — ensuring that you’re not ingesting any unwanted chemicals alongside your hemp extract.

How do you deal with CBD and dry mouth? Share your life hacks in the comment section below!


  1. Prestifilippo, J. P., Fernández-Solari, J., de la Cal, C., Iribarne, M., Suburo, A. M., Rettori, V., McCann, S. M., & Elverdin, J. C. (2006). Inhibition of salivary secretion by activation of cannabinoid receptors. Experimental biology and medicine (Maywood, N.J.), 231(8), 1421–1429. https://doi.org/10.1177/153537020623100816
  2. Shannon, S., Lewis, N., Lee, H., & Hughes, S. (2019). Cannabidiol in Anxiety and Sleep: A Large Case Series. The Permanente journal, 23, 18–041. https://doi.org/10.7812/TPP/18-041
  3. Kirkham T. C. (2009). Cannabinoids and appetite: food craving and food pleasure. International review of psychiatry (Abingdon, England), 21(2), 163–171. https://doi.org/10.1080/09540260902782810
  4. Jadoon, K. A., Tan, G. D., & O’Sullivan, S. E. (2017). A single dose of cannabidiol reduces blood pressure in healthy volunteers in a randomized crossover study. JCI insight, 2(12), e93760. https://doi.org/10.1172/jci.insight.93760
  5. Iffland, K., & Grotenhermen, F. (2017). An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies. Cannabis and cannabinoid research, 2(1), 139–154. https://doi.org/10.1089/can.2016.0034
Nina Julia

Nina created CFAH.org following the birth of her second child. She was a science and math teacher for 6 years prior to becoming a parent — teaching in schools in White Plains, New York and later in Paterson, New Jersey.

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The Potential Side Effects of CBD

Wendy Rose Gould is a lifestyle reporter with over a decade of experience covering health and wellness topics.

Verywell Mind articles are reviewed by board-certified physicians and mental healthcare professionals. Medical Reviewers confirm the content is thorough and accurate, reflecting the latest evidence-based research. Content is reviewed before publication and upon substantial updates. Learn more.

Steven Gans, MD is board-certified in psychiatry and is an active supervisor, teacher, and mentor at Massachusetts General Hospital.

Verywell Mind content is rigorously reviewed by a team of qualified and experienced fact checkers. Fact checkers review articles for factual accuracy, relevance, and timeliness. We rely on the most current and reputable sources, which are cited in the text and listed at the bottom of each article. Content is fact checked after it has been edited and before publication. Learn more.

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Verywell / Alex Dos Diaz

Generally speaking, CBD is considered a safe substance when applied topically or taken orally. There are, however, some potential side effects to keep in mind when using this substance, the majority of which are mild.

Common Side Effects of CBD

The most comment side effects of CBD include drowsiness, gastrointestinal issues, dry mouth, reduced appetite, nausea, and interaction with other medications. Those are outlined in detail below.


Some common side effects when using CBD include drowsiness and sedation. This is also considered a benefit, but Dr. Jas Matharu-Daley, a physician and chief medical officer for a CBD brand, notes that the effects might be too strong if you’re also taking CBD with other sedating medications.

Gastrointestinal Issues

Some people may get diarrhea or liver problems [when using CBD]. This is dependent on the individual and their medical history, so monitoring is important,” says Dr. Matharu-Daley.

Dry Mouth

Also known as “cotton mouth,” CBD can potentially cause your mouth and eyes to feel very dry. Though this side effect is more likely to occur with THC, it can happen with CBD as well.

Can Interact With Other Medications

CBD might interfere with the other medications you take. Dr. Matharu-Daley says it’s important to talk to your doctor about whether CBD could affect your existing prescriptions.


In some cases, those who ingest CBD supplements might experience nausea, says Dr. Matharu-Daley. This depends on how sensitive the person is to CBD, as well as the amount they ingest.

Because CBD supplements come in so many different forms—such as oils, gummies, tinctures, and vapors—the amount that’s actually absorbed can vary drastically. This, combined with each person, will ultimately affect which (if any) CBD side effects you might experience.

What Is Cannabidiol (CBD)?

CBD—the abbreviation for cannabidiol, a substance that’s generally derived from the hemp plant—has skyrocketed in popularity over the last five years. In fact, according to research, “CBD” as a Google search term remained stable from 2004 to 2014 but has since ballooned by up to 605%.

CBD is one of the many chemical compounds that is found in the cannabis plant—referred to as cannabis sativa. There are two primary parts of the plant that humans use. One is THC, or Delta-9-Tetrahydrocannabinol, and the other is CBD. Though they’re from the same plant, THC and CBD are quite different from each other.

“CBD is not an intoxicating substance, whereas THC is a psychoactive that can get you high,” explains Dr. Jas Matharu-Daley, a physician and consultant for a brand that specializes in CBD production.

Are There Any Benefits Associated With Using CBD?

There are several reasons why someone might want to use CBD. The substance can be found in a multitude of products ranging from pain-relieving creams to edible tinctures to skincare. Research is still underway, but over the last few decades scientists have become more aware of how CBD might be beneficial when applied either topically or ingested.

“Since discovering the endocannabinoid system (ECS) in the body in the 1990s, CBD has been researched more extensively. The ECS is a central regulatory system restoring normal balance and homeostasis in a range of human physiologic systems throughout the body and brain and has cannabinoid receptors and chemicals in its function,” explains Dr. Matharu-Daley.

CBD benefits include the following:

  • CBD can have positive impact on the brain. In fact, Dr. Matharu-Daley says that the substance is legally prescribed in a specific medication for certain severe forms of epilepsy in children.
  • It has also been shown to have anti-inflammatory properties, which is why you often see CBD in topical products such as oils, creams, and lotions.
  • Some research points to CBD’s ability to relieve stress and anxiety.
  • It has been used as a nausea treatment in some countries.
  • CBD may potentially reduce pain symptoms.
  • It has antioxidant properties, which means it can help fight off free radical damages that leads to premature aging.
  • Regarding skincare, CBD may help reduce excessive oil production in those with very oily skin types.

Ultimately, the primary reasons why people use CBD is because it tends to have calming, relaxing, pain-reducing effects. It has been used to alleviate joint pain and nerve pain, reduce anxiety and stress, treat insomnia, improve migraines, and address nausea.

CBD Is Still an Unregulated Substance

It’s important to point out that CBD is not regulated by the FDA and therefore dosages might not be accurate. It’s also difficult to know what an appropriate dose is the first time you try a new product.

“If the CBD is from a reputable source and one that has been inspected by a third-party independent lab, the content of CBD is more reliable,” notes Dr. Matharu-Daley. “The CBD should be organically grown, free of pesticides and heavy metals, and not sourced in food which can affect absorption. Generally, CBD is safe and side effects are few at low doses.”

A Word From Verywell

CBD is technically an unregulated substance in the United States and therefore it ought to be used with caution. This is especially important for those taking additional medications and/or those with ongoing medical issues. That said, preliminary research on CBD and its benefits are promising in relation to helping with mild to moderate health concerns and it is generally considered a safe substance. Health professionals do not consider CBD a cure-all for serious medical issues, including cancer.

As with any sort of supplement, we recommend speaking to your medical doctor about whether using CBD makes sense for you. Your doctor can also recommend certain products that align with your needs and help ensure you get the correct dosage.

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