CBD Oil And Prednisone


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No, it is not safe to use CBD oil while taking Prednisone simultaneously. CBD can inhibit CYP3A in the body. Read more. When you take CBD alongside certain medications, it can trigger negative drug interactions. Here we explain what drugs shouldn’t be taken with CBD — and when to consult your doctor if you’re not sure about the potential interactions. CBD, a popular alternative treatment in treating inflammation, may worsen the side effects of the anti-inflammatory drug prednisone if used together.

Can you safely take CBD oil with Prednisone?

I’ve heard that CBD can interact with many drugs. Are there interactions with Prednisone and CBD oil?

Joel Taylor (Thursday, August 12, 2021):

Both CBD oil and Prednisone are inhibitors of the cytochrome P450 enzyme CYP3A, which means that taking both of them together would result in them having to compete for metabolism. What this means is that the interactions with CBD oil and Prednisone could be dangerous, potentially leading to increased side effects from both. If you are on Prednisone or any other medication, you should talk to your doctor before deciding to try CBD oil as well. Additionally, give it a few hours in between doses to minimize adverse reactions as much as possible.

Osasere Okunloye (Thursday, August 12, 2021):

Studies show that CBD can interact with Prednisone by inhibiting the same enzyme (Cytochrome P450 enzyme CYP3A) as prednisone, and using both of them together may decrease glucocorticoid clearance and increase side effects of Prednisone. Before taking CBD with prednisone or any other medication, you should seek professional advice from a doctor. Reply Follow Share Avik Das Wednesday, January 12, 2022 No, it is not safe to use CBD oil while taking Prednisone simultaneously. CBD can inhibit CYP3A in the body, but Prednisone is also known to inhibit CYP3A in the body. Therefore, using them together might give good results in glucose clearance, but facing systemic side effects is inevitable. It is always best to consult a doctor before using CBD oil with Prednisone.

What Are Some Benefits Of Taking CBD Oil?

CBD oil interacts with your Endocannabinoid system to help control your physiological responses. Taking CBD oil can help you de-stress, and relax, such as via Cannabotech’s Relax drops and Beauty Sleep drops.

CBD oil can also help relax your muscles after a workout, try Unwind Tablets.

CBD Drug Interactions – Mixing Cannabidiol and Medications

Are you worried about potential CBD-drug interactions? In this article, we explain the mechanism behind drug metabolism and how CBD may interfere with it.

The range of therapeutic properties offered by CBD (cannabidiol) has spurred its popularity in recent years. This natural compound is known to relieve a host of symptoms, allowing for safer and more effective management of different health conditions.

And unlike THC (tetrahydrocannabinol), CBD is non-intoxicating, so it won’t get you high.

CBD can assist in the treatment of anxiety disorders and depression, inflammation and pain, neurodegeneration, seizure disorders, sleep deprivation, metabolic conditions, neuropathy, migraines, inflammatory bowel disease, and more.

Considering CBD has so many potential health benefits, you may start wondering if it can interact with certain medications used to address the same symptoms — and whether you should or shouldn’t take these drugs with CBD.

Below you’ll find the dos and don’ts of using CBD along with medications.

Let’s start with the don’ts.

What Drugs Should Not Be Taken with CBD

Studies from the Indiana University Department of Medicine have provided a list of pharmaceutical drugs and medications which shouldn’t be taken with CBD.

The list below covers all groups of drugs that can negatively interact with CBD oil.

  • Angiotension II Blockers
  • Antiarrhythmics
  • Antibiotics
  • Antidepressants
  • Anticonvulsants / Anti-Seizure Medications
  • Antihistamines
  • Antipsychotics
  • Anesthetics
  • Beta-Blockers
  • Benzodiazepines
  • Calcium Channel Blockers
  • HIV Antivirals
  • HMG CoA Reductase Inhibitors (Statins)
  • Immune Modulators
  • Non-Steroidal Anti-Inflammatory Drugs
  • Oral Hypoglycemic Agents
  • Proton-Pump Inhibitors (PPIs)
  • Prokinetics
  • Steroids and Corticosteroids
  • Sulfonylureas

There’s also a group of drugs called “prodrugs” that first need to be processed into their therapeutic compounds instead of being therapeutic compounds on their own. In plain English, the inactive compound is consumed, and once in the body, it turns into the active compound.

If this mechanism is dependant on the CYP450 system (more on that later), a drug interaction can lead to insufficient concentrations of the therapeutic agent in the bloodstream — reducing its potency.

CBD Interaction with Drugs & Medications

This section covers the most common interactions between CBD and medications. If you take any of the substances listed below, make sure to consult your doctor before buying CBD oil.

CBD and Ibuprofen Interaction

Ibuprofen is one of the Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), meaning it can produce similar benefits to CBD in terms of inflammation and pain relief. Previously we’ve mentioned that NSAIDs interact with CBD, which may raise concerns about potential negative interactions between CBD oil and Ibuprofen.

According to a study from the Journal of Neurology Research, there have been no reported interactions between CBD and ibuprofen, although it doesn’t mean they do not exist. Health experts suggest that potential interactions may be dosage-dependent. If a certain dosage threshold is breached, CBD and NSAIDs like Ibuprofen can lead to unforeseen and potentially severe nervous system pathology.

CBD and Adderall Interaction

A 2020 study found that higher doses of medical cannabis led to a decreased use of ADHD medication in adults. Products containing a higher concentration of CBD were linked to lower ADHD scores. This means that CBD can interact with ADHD meds, decreasing their efficacy while providing more pronounced benefits. The potential side effects of interactions between CBD and Adderall may lead to decreased appetite.

CBD and Lamictal Interaction

Using medical cannabis and Lamictal may increase side effects such as dizziness, confusion, drowsiness, and difficulty concentrating. Elderly consumers may also experience impairment in judgment. That being said, none of these side effects were proven to result from CBD use per se. When it comes to interactions between CBD and Lamictal, it can make the medication more or less effective, depending on the dosage.

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CBD Oil and Antibiotics

There is no known interaction between CBD and antibiotics, although these interactions may occur if an antibiotic is metabolized through the cytochrome P450 enzyme system. Some studies indicate that taking CBD and antibiotics together may amplify the effects of one another without any negative side effects. However, more research is needed to confirm these findings on a larger scale.

CBD Oil and Omeprazole

CBD can inhibit the enzymes that are targeted by omeprazole and other Proton Pump Inhibitors (PPIs). Taking CBD with certain heartburn medications can increase the risk of diarrhea.

CBD and Thyroid Medications

Some people report mild nausea when taking CBD oil together with their thyroid medications. Since both substances are processed by the CYP450 enzyme system, taking CBD with a thyroid medication may cause hyperthyroidism because more thyroxine would be secreted than the body could metabolize.

CBD and Lisinopril

CBD can temporarily lower blood pressure, so taking it alongside medications like Lisinopril might reduce it even more, making you feel lethargic and weak. Always consult your doctor before adding CBD to your routine if you use anti-hypertension meds.

CBD and Prednisone

Since both CBD and corticosteroids are potent inhibitors of the CYP450 enzyme system, concomitant use may increase the risk of systemic side effects from corticosteroid use due to decreased glucocorticoid clearance. Corticosteroids like prednisolone and hydrocortisone should never be taken with CBD.

How Drugs Interact: Understanding Drug Metabolism

Metabolism can refer to how your body uses energy for weight management, or the way drugs are metabolized in your body.

The former is known as the basal metabolic rate, or in simple terms, the number of calories a person needs to maintain healthy body functions while at rest.

The latter is very different from the basal metabolic rate. Drug metabolism refers to how a substance is processed and used by the body — with the majority of this processing happening in the liver.

Scientists call it the ‘first-pass effect’ or ‘first-pass metabolism.’

Using straightforward terms, when you take a medication, it is broken down in the liver into its active compounds so that the body can use them. Just like carbohydrates are broken down into sugars, fats into triglycerides, and proteins into amino acids — drugs break down into their individual ingredients.

From there, they are controlled by specific enzymes, which transform these compounds into metabolites. These metabolites then influence different processes in your body and are flushed with urine once used up.

How Is CBD Metabolized?

Drug metabolism determines the rate at which the body processes medications and other therapeutic compounds into their individual metabolites and how long they can stay in your system.

When you take CBD in the form of an oil, capsule, or gummy, it has to pass through your gut, where it is released into the bloodstream. From then, they travel through the bloodstream to the liver, where it absorbs through the hepatic portal. The liver breaks CBD down into its metabolites using enzymes, after which it can circulate throughout the body in the bloodstream again.

What Is the Cytochrome P450 System?

Aside from breaking compounds down into metabolites, the liver also detoxifies and excretes foreign substances and other types of toxic compounds. This can happen through a system of enzymes referred to as the Cytochrome P450 (CYP450). These enzymes contain heme as a cofactor to convert cannabinoids into more water-soluble molecules, increasing their absorption and efficacy.

Researchers estimate that the CYP450 system is responsible for metabolizing 60% of any drugs out there. And interestingly, doctors and pharmacists use this system to understand, evaluate, and predict the benefits of the drug and potential side effects based on their dosages.

However, certain compounds have the ability to compromise the CYP system’s functioning, negatively affecting the metabolism of certain medications. Once these interactions occur, the drugs can be metabolized faster or slower than normal.

CBD And the Cytochrome P450 System

As mentioned earlier, CBD can interact directly with the CYP450 system in the liver. According to preclinical studies, CBD binds to the site where the enzyme activity occurs, competing with other compounds and thus preventing this system from breaking down other substances.

This inhibitory effect on the CYP450 enzymes mainly depends on how much CBD a person takes, their unique physiology, and the type of CBD used (e.g., full-spectrum CBD vs. CBD isolate). The dosage determines the strength used by the CBD to bind to the active site of the metabolic enzymes. The tighter the bond, the more competitive inhibition.

Contraindications for Taking CBD with Medications

The mechanism behind CBD’s health benefits proves that it’s not a biologically inert compound. Instead, the pharmacokinetics and pharmacodynamics of CBD are complex and similar to any other medication. Therefore, it has the potential to compromise the metabolism of certain medications.

Any therapeutic substance that relies on the CYP450 system can be potentially affected by CBD. A common indicator for such interaction is when your medication has a grapefruit warning on the bottle. However, this is by no means a solid point of reference, and you should always check with your doctor and pharmacist before taking the two compounds together.

Why You Should Always Consult Your Doctor First

The list of drugs that we’ve mentioned above is by no means definite and doesn’t include all the pharmaceutical substances that may interact with CBD. Similarly, not all the medication from these categories will necessarily cause an interaction — as is the case for antibiotics and Ibuprofen.

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A consultation with a doctor experienced in CBD and cannabis use can help you establish the right routine for your medications and supplements to avoid potentially negative interactions. Some compounds work synergistically with CBD, so asking your doctor can help you maximize the effect of your treatment.

Not to mention that the doctor can guide you on finding the optimal dosage for yourself.

Key Takeaways on CBD Drug Interactions

The safety profile of CBD has been acknowledged by major health agencies, such as the World Health Organization (WHO), showing that it’s well-tolerated by animals and humans and rarely produces any dangerous side effects.

CBD also has a profound impact on an array of systems, which explains its therapeutic versatility. That being said, this versatility is also the reason why CBD interacts with so many prescription meds and over-the-counter (OTC) PRODUCTS.

Again, if you’re not sure if CBD will interact with the medication that you might be taking, a consultation with a health professional will not harm — unlike trying to figure out these interactions on your own.

Livvy Ashton

Livvy is a registered nurse (RN) and board-certified nurse midwife (CNM) in the state of New Jersey. After giving birth to her newborn daughter, Livvy stepped down from her full-time position at the Children’s Hospital of New Jersey. This gave her the opportunity to spend more time writing articles on all topics related to pregnancy and prenatal care.

Does CBD Interact With Prednisone (Rayos)?

Information on risks & possible interactions between CBD & prednisone.

Article By

Prednisone (Rayos) is a common steroid medication used for inflammation and pain. It’s highly effective but comes with a long list of potential side effects. CBD is sometimes used as an alternative, and many take both of them together.

Is it safe to take CBD and prednisone together? What are the risks?

Learn about the potential interactions between these infamous anti-inflammatory substances.

Table of Contents

Does CBD Interact With Prednisone (Rayos)?

Due to the many side effects associated with prednisone, CBD may be a safer alternative.

CBD can inhibit the action of CYP3A4, a liver enzyme that metabolizes several kinds of drugs, including prednisone. Because of its inhibitory activity, it can cause the enzyme to slow down. This could cause the metabolism of prednisone to slow down as well, meaning prednisone would remain in the system for a longer time frame and more liable to cause more side effects.

CBD also interacts with many other kinds of drugs. These are divided into three main categories. They are:

1. Increased Effect (Agonistic Interaction)

This interaction happens when two substances have the same effects in the body due to both of them acting on the same receptors to push in the same direction.

Because CBD and prednisone share many of the same effects, the combination could potentially lead to side effects.

2. Slowed Elimination (Metabolic Competition)

All drugs need to be metabolized by the liver, including CBD.

A metabolic competitor refers to substances that require the same pathway for metabolism. This causes both compounds to compete for metabolism, leading to buildups and a slow breakdown of both compounds.

CBD and prednisone are both metabolized by CYP3A4 and may compete for metabolism, increasing the duration of effects of both substances.

Taking either CBD, prednisone, or both substances daily may lead to gradual buildups in the blood, causing harmful side effects to occur.

Other Names For Prednisone

Prednisone is sold under many different names. All share the same risk and potential interactions.

Other names for prednisone include:

Similar Medications: CBD & Immunosuppressants

Prednisone is classified as an immunosuppressant. CBD and immunosuppressants all share similar risks for interaction and side effects.

Here’s a list of similar medications that share an equal level of risk when combined with CBD:

  • Azathioprine (Imuran)
  • Mycophenolate Mofetil (Cellcept)
  • Cyclosporine (Neoral, Sandimmune, Gengraf)
  • Methotrexate (Rheumatrex)
  • Leflunomide (Arava)
  • Cyclophosphamide (Cytoxan)
  • Chlorambucil (Leukeran)
  • Nitrogen Mustard (Mustargen)

Is It Safe to Take CBD & Prednisone (Rayos) Together?

CBD and prednisone can be taken together safely, but the dose of both substances may need to be modified. Always ask your doctor about taking CBD if you have a prescription for prednisone.

Is CBD a Viable Alternative to Prednisone (Rayos)?

There is not much research about how effective CBD is in treating symptoms of inflammation and other conditions like the ones that prednisone treats, so it cannot be considered an adequate alternative to prednisone.

All available information shows CBD could treat inflammation, but its efficacy and potency are still being evaluated. It is best to consult your doctor first before deciding to switch to CBD.

What Is Prednisone (Rayos)?

Prednisone (Rayos) is a type of glucocorticoid. It was first discovered in 1955 by Schering Corporation under the brand name Meticorten and Delta-Cortef. It got its approval for use by the FDA in 2012.

Prednisone is a synthetic pregnane corticosteroid and a derivative of cortisone.

Prednisone is used in the treatment of asthma, COPD, rheumatologic diseases, neoplasia, etc. It can also treat high blood calcium due to cancer and adrenal insufficiency.

Prednisone Specs:

Drug Name Prednisone
Trade Name Deltasone, Liquid Pred, Meticorten, Orasone, Rayos, Prednisone Intensol, Sterapred, Sterapred DS
Classification Corticosteroid
CYP Metabolism Cytochrome P450
Interaction With CBD Metabolic competitor
Risk of Interaction Moderate

What Does Prednisone (Rayos) Do?

Prednisone is a synthetic steroid. This drug has anti-inflammatory and immunomodulating properties.

Prednisone is a prodrug that gets hydroxylated to an active metabolite form called Prednisolone. This form controls its glucocorticoid effects. This hydroxylation process may get impaired in liver disease.

Inflammation is the body’s natural response to injury or infection of any kind. The immune system works to contain and eliminate the pathogens that are causing the inflammation. It causes redness, swelling, raised temperature over the affected part, and pain. In chronic conditions such as arthritis, inflammations can cause constant pain and may decrease the functionality of the organs.

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Prednisone decreases inflammation by suppressing the migration of the polymorphonuclear leukocytes and reversing the raised capillary permeability that happens in inflammation.

It also stops the multiple inflammatory genes activated in inflammatory diseases and suppresses the immune system by decreasing its activity and volume. It has antineoplastic effects, which it does by stopping glucose transport and inducing the death of immature lymphocytes.

Prednisone gets metabolized by the CYP450 enzymes in the liver, including the CYP3A4 enzyme.

What Are the Side Effects of Prednisone (Rayos)?

Common prednisone side effects include:

  • Acne
  • Blurred vision
  • Changes in behavior or mood
  • Elevated blood pressure levels
  • Elevated blood sugar levels
  • Fluid retention
  • Headache
  • Nausea
  • Restlessness and inability to stay still (akathisia)
  • Sleep problems

Serious side effects of prednisone are:

  • Hypersensitivity
  • Osteoporosis, bone loss, and fractures, osteonecrosis
  • Increased risk of infection
  • Cardiovascular problems like atherosclerosis, hypertension, etc
  • Skin problems like impaired wound healing, striae, urticaria, allergic dermatitis, and others
  • Abnormal fat deposits
  • Diabetes Mellitus
  • Gastric ulcer and GI bleeding
  • Corticosteroid induced psychosis
  • Glaucoma
  • Depression

Contraindications of Prednisone (Rayos)

Prednisone should not be taken in some conditions. They are:

  • Untreated serious infections
  • Known hypersensitivity to prednisone
  • Varicella
  • Administration of live or attenuated live vaccine

Some Important Points to Know About Prednisone (Rayos)

There are some points that you should know about before using this medication. These are:

A) Stopping Prednisone

This drug is similar to cortisol, a hormone produced by the adrenal glands that regulate many functions. If prednisone is used for a long time, say a few weeks to months, the adrenal glands will decrease their cortisol production.

If you stop taking this medication abruptly, your body may go into symptoms like prednisone withdrawal, so gradual tapering is needed. Some of the withdrawal symptoms of stopping prednisone consist of fatigue, joint pains, stiffening of muscles, and fever.

B) Prolonged Use of Prednisone

Prolonged use of this drug can cause several unwanted effects in the body. These include an increased risk of infection, osteoporosis, delayed wound healing, elevated intraocular pressure, glaucoma, cataracts, and reactivation of latent tuberculosis.

C) Monitoring the Patients

It is of great importance to monitor patients taking prednisone as it may cause hypothalamic-pituitary-adrenal (HPA) axis suppression, Cushing syndrome, hyperglycemia, and psychiatric disturbances.

D) Use In Various Diseases

Prednisone can be given in low doses for some chronic diseases, including liver diseases, hypertension, thyroid disorders, osteoporosis, kidney diseases, diabetes mellitus, and gastrointestinal disorders. However, caution is necessary. Patients receiving this medication should avoid chickenpox or measles-infected persons if unvaccinated.

E) Use In Pregnancy & Lactating Mothers

Prednisone can be dangerous in pregnancy as it can cause harm to the fetus. It also increases the risk of cleft palate. It is expressed in the milk in lactating mothers and may cause problems in the baby, so the lowest dose must be used.

Because of the many adverse effects of prednisone, more users are searching for natural alternatives like CBD to treat inflammations.

What Is CBD (Cannabidiol)?

Cannabidiol or CBD is the second most common compound extracted from the Cannabis sativa plant. It’s usually inhaled or taken orally. It does not cause intoxication and isn’t psychoactive, unlike some other cannabinoids.

Cannabidiol has been undergoing research for its role in treating inflammation, anxiety, cognition, movement disorders, and pain [1, 2]. Epidiolex, a drug containing cannabidiol, has been approved by the FDA for treating two epilepsy conditions.

Also, a 1:1 combination of CBD and tetrahydrocannabinol (THC), another cannabis extract, can treat spasticity in multiple sclerosis.

How Does CBD Work?

CBD can interact with the endocannabinoid system (ECS), a biological system containing endocannabinoids, a type of neurotransmitters. These endocannabinoids bind to the cannabinoid receptor proteins. The ECS is vital for conducting neural functions and balances cognitive processes, pain sensation, and mood.

There are two primary cannabinoid receptors, CB1 and CB2. CB1 receptors are present mainly in the brain and central nervous tissues.

CB2 receptors can be found in peripheral organs, especially the immune system. THC, cannabis’ main component, binds to CB1 directly and mediates its psychoactive properties.

However, CBD alters the action of the receptors that bind to the cannabinoids. CBD can interact with CB2 receptors, induce vasodilation, turn off the inflammatory reaction, and activate 5HT1A receptors that provide therapeutic relief in diabetic neuropathy. It also helps decrease oxidative stress and inflammation [3].

CBD is metabolized in the liver by cytochrome P450 enzymes such as CYP1A1, CYP1A2, CYP1A22, CYP1B1, CYP2B6, CYP2C19, CYP2D6, CYP3A4, and CYP3A5.

CBD is also a competitive inhibitor for these same enzymes. It can occupy sites of enzymatic activity and can displace its chemical competitors. Due to this, the enzymes of cytochrome P450 will be unable to metabolize other compounds.

Side Effects of CBD

There are some side effects of CBD that one should know. They are:

  • Mouth dryness
  • Decreased appetite
  • Drowsiness
  • Fatigue
  • Allergy

Key Takeaways: Is It Safe to Take Prednisone (Rayos) With CBD?

CBD is well-tolerated in the general population and has shown effectiveness in treating inflammations just as prednisone (Rayos) can. However, both these drugs can interact with each other and worsen each other’s effects. Consult your doctor first before using CBD.

Also, if you plan on using CBD, you need to taper prednisone gradually. Only when it is certain that the two drugs will not interact with each other can you start with CBD.

There’s ongoing research on CBD’s therapeutic effects, so perhaps we’ll find out more about its uses and interactions with time.

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