A daily dose of baby aspirin can help reduce the risk of heart attack, but how does this NSAID drug interact with CBD? Learn more about the potential side effects on Remedy Review. CBD interaction with Aspirin: Does taking them together negatively affect health? Find out more about how the drugs interact and the effects of their combination below.
CBD and Baby Aspirin—What You Need to Know
Aspirin is a non-steroidal anti-inflammatory drug (NSAID) that has many different uses, including reduced fever, pain, and risk of blood clots. Baby aspirin has the same effects but comes in smaller doses, which helps reduce the potential for negative side effects of excessive NSAID use.
Cannabidiol (CBD) has been touted for its many wellness benefits, some of which are described as having similar pain relieving properties as baby aspirin. But you should know these come with side effects, too. More clinical research is needed to determine the full therapeutic potential of CBD.
Given the current knowledge on this cannabinoid, it’s also uncertain how baby aspirin and CBD may interact with one another. To help answer this question, we dug a little deeper to assess the similarities and difference between the two, and what to avoid.
Why do people take baby aspirin?
For people with diabetes, high cholesterol, and other heart disease risk factors, aspirin is one of the best ways to prevent against heart attacks. Aspirin does so by stopping the formation of blood clots, which are the primary cause of heart attacks. These clots block the flow of oxygen-rich blood to a section of the heart, and may cause serious damage if not treated quickly enough.
While aspirin presents some advantages when it comes to reducing a person’s risk of heart attack, it also has some negative effects. The blood thinning properties of this drug can cause severe nausea, vomiting, or stomach pain, just to name a few of the most common side effects. Because of this, baby aspirin has become a safer option for many patients since it offers the same preventative advantages, but reduces the chance of serious internal bleeding.
Can CBD lower your risk of heart attack?
CBD is perhaps best known for its anti-inflammatory and analgesic properties, which contributes to the many soothing qualities that people often report experiencing when they use CBD oil. In terms of heart health, it can be difficult to measure the success of a wellness supplement like CBD, although some scientific evidence has helped uncover the effects CBD may have on cardiovascular health.
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In a review published by the British Journal of Clinical Pharmacology, the authors analyzed several studies and preclinical data to conclude that CBD might positively affect the cardiovascular system. These observations were most frequently observed in rats, where CBD exhibited the ability to reduce the cardiovascular response to stress, decrease myocardial inflammation, and provide some cardioprotective benefits. However, it’s unclear the exact mechanisms that CBD acts upon to facilitate these results, and the full extent of how this cannabis compound may affect humans.
CBD has also demonstrated anti-arrhythmic advantages, which are not directly correlated to the prevention of heart attacks, but are worth mentioning given the various causes of heart arrhythmias. These irregular heartbeats can happen as a result of high blood pressure, blocked arteries, heart scar tissue, stress, diabetes, and heart attacks when they are happening in the moment.
Some evidence supports the use of CBD for positive heart health benefits, but CBD is not a proven treatment option in the same way that baby aspirin is. The blood thinning properties of aspirin are linked directly to blood clot reduction and heart attack prevention. In addition, more research is needed to analyze and assess the therapeutic potential of CBD for heart attacks and heart related diseases.
Potential Risks of Mixing CBD with Baby Aspirin
CBD has become a popular wellness supplement for a wide range of ailments, but there is still much that we don’t know about this cannabinoid. The World Health Organization notes that cannabidiol is “generally well tolerated with a good safety profile,” but this does not account for potential drug interactions between CBD and other medications. For instance, CBD might increase the level of certain medications in your blood, which could interfere with the efficacy or side effects of the drug.
Because of the many unknowns that surround CBD, we don’t recommend mixing CBD supplements and baby aspirin together. They may interact with the heart in different ways or CBD might increase the blood thinning properties of baby aspirin, which could have potentially dangerous side effects, such as:
- Intestinal bleeding
- Gastrointestinal ulcers
- Bleeding in the brain
- Stomach ache
- Nose bleeds
Before taking CBD, it’s best to check with your doctor, especially if you have a medical condition that you are currently seeking treatment for.
Does CBD Interact with Aspirin (Acetylsalicylic Acid)?
Information on risks & possible interactions between CBD & aspirin.
Cannabidiol or CBD is a non-psychoactive cannabinoid derived from the Cannabis sativa plant commonly used to manage chronic pain and inflammation.
Aspirin (acetylsalicylic acid) is another common painkiller bought over the counter at drugstores and supermarkets.
Despite similar effects, the level of risk for interaction between these two substances is minimal.
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Does CBD Interact With Aspirin?
CBD is unlikely to interact with low-dose Aspirin.
However, with higher doses or long-term use, CBD could, theoretically, increase serum levels of Aspirin over time — leading to potential side effects.
Both CBD and Aspirin are considered blood thinners and analgesics. It’s possible that this combination could lead to an increase in side effects associated with those effects — including the formation of bruises, blood loss, or liver damage.
However, in practice, none of these side effects have been reported and people who use both supplements on a daily basis rarely, if ever, experience any notable side effects.
Other Names for Aspirin
Aspirin is the generic name for acetylsalicylic acid (ASA). It’s sold under many different names. All share the same risk and potential interactions.
Other names for Aspirin include:
- Norwich Aspirin
Similar Medications: CBD & NSAIDs
Acetaminophen is classified as an NSAID (non-steroidal anti-inflammatory drug). CBD and NSAIDs all share similar risks for interaction and side effects.
Here’s a list of similar medications that share a similar level of risk when combined with CBD:
- Ibuprofen (Motrin, Advil, Nuprin, Caldolor & Neoprofen)
- Celecoxib (Celebrex & Onsenal)
- Naproxen (Aleve)
- Ketorolac (Toradol)
- Etodolac (Ultradol)
- Meloxicam (Mobic)
Is It Safe to Take CBD & Aspirin Together?
It’s safe to take CBD along with low-dose Aspirin in most cases. If you’ve been prescribed high potency Aspirin, or are taking Aspirin on a daily basis to manage the risk of heart disease, it’s a good idea to speak with your doctor before starting CBD.
While it’s unlikely CBD is going to interact with Aspirin directly, it may be contraindicated for certain types of heart disease.
Is CBD a Viable Alternative to Aspirin?
CBD is widely used for several benefits, the main ones being pain relief and management of anxiety.
For mild to moderate pain and inflammation, CBD may be a viable, and potentially even more effective option than Aspirin.
For use as a blood thinner, CBD is not comparable to Aspirin and is not considered a viable alternative.
What is Aspirin?
Aspirin, and its generic component acetylsalicylic acid (ASA). It’s a medication commonly used for the treatment of pain, inflammation, and fever. It’s classified as a non-steroidal anti-inflammatory drug — NSAIDs for short.
It’s widely prescribed to patients with cardiac disorders such as heart attack, heart failure, or cardiac arrests as a blood thinner that will prevent any blood clots from forming, and consequently, producing a cardiac injury.
Aspirin is readily available in pharmacies and does not need a doctor’s prescription before it can be purchased from these pharmacies. The drug is manufactured by different pharmaceutical companies and, hence, is available under different trade names, such as Bayer, Easprin, Ecotrin, and Ecoprin, to name a few.
Aspirin has a half-life of either 2 hours to 3 hours, or 15 hours to 30 hours, depending on the dose, with the former being the half-life of 100 mg or less of Aspirin. The drug is excreted mostly through the urine, almost 80 percent, and the rest is excreted via feces and sweat.
|Drug Name||Aspirin (Acetylsalicylic acid)|
|Trade Name||Aspirin, Aspro Clear, Bayer, Disprin, Easprin, Ecotrin, Ecoprin, Entercote|
|Classification||Non-Steroidal Anti-inflammatory Drug (NSAID)|
|CYP Metabolism||Liver (CYP2C19 and CYP3A)|
|Interaction with CBD||Agonistic (Increased effects)|
|Risk of Interaction||Low|
What Does Aspirin Do?
Aspirin is used to treat a number of medical conditions that present with symptoms such as fever, pain, and inflammation. It’s one of the most commonly prescribed medications in cardiology clinics as its blood-thinning abilities are crucial for patients who have recently suffered from a heart attack or a stroke.
The mechanism of action of Aspirin includes irreversible inhibition of the enzyme, Cyclooxygenase or COX, which is crucial for the synthesis and distribution of prostaglandins and thromboxane in the body.
There are two different types of cyclooxygenases in the human body, namely COX1 and COX2 enzymes with the former being responsible for the production of thromboxanes, a hormone responsible for vasoconstriction and platelet aggregation in the blood vessels.
COX1 is irreversibly inhibited by Aspirin, whereas COX2, the enzyme responsible for the production of the hormone prostaglandins which induces the release of pro-inflammatory cytokines, activity is modified by the drug.
COX2 activity modification results in the conversion of the enzyme’s ability to produce prostaglandins to producing a lipoxygenase enzyme which helps with the metabolism of different polyunsaturated fats in the human body.
The inhibitory effect of Aspirin on the COX1 enzyme helps the medication manage bleeding as irreversible inhibition of thromboxane A2 in platelets inhibits platelet aggregation for 7 days to 8 days, the life span of the affected platelet. This mechanism is responsible for the prescription of Aspirin to patients with a history of heart attack, strokes, transient ischemic attack, and unstable angina, to help prevent recurrence of these medical emergencies.
Prostaglandins play a huge role in the information transmission from the brain to the different parts of the body suffering from pain and inflammation. They are also known to have an effect on the regulation of the hypothalamus’ thermal center, hence altering body temperature and interrupting the body’s temperature homeostasis.
Inhibition of these prostaglandins by inhibiting the enzyme required for their synthesis is essential for the management of pain and inflammation in the body. Aspirin can manage and treat fever-like symptoms by inhibiting these hormones and inducing proper regulation of body temperature.
Irreversible inhibition of local hormones in the body, and eventually platelet aggregation is what separates Aspirin from other NSAIDs such as Ibuprofen and Diclofenac as they are reversible inhibitors.
Adverse Effects of Aspirin
Aspirin is a widely available, over-the-counter medication that is used by almost all age groups. However, it’s crucial to keep in mind the fact that there are several side effects of this medication that need to be considered.
Aspirin use is contraindicated in pregnancy, especially after the 20th week of pregnancy as it can result in kidney disorders in the fetus as a result of decreased levels of amniotic fluid.
Moreover, it isn’t recommended to be used in children with influenza or the common cold, as it can result in the development of a nearly fatal, progressive brain disease known as Reye’s Syndrome. The use of this medication is contraindicated to patients on warfarin treatment or those with disorders affecting the lining of the stomach such as peptic ulcers and gastritis. The medication should not be taken with alcohol.
Some of the common side effects of Aspirin include:
- Skin rash
- Gastrointestinal ulcers
- Abdominal pain
- Abdominal cramping
- Abdominal distress
Aspirin should not be used if there is a history of gastrointestinal disorders, without the recommendation of a healthcare professional.
Some of the more severe side effects of Aspirin include:
- Retinal vein occlusion
- Cerebral microbleeds
- Reye Syndrome
- Gastrointestinal bleeding
Types of Drug Interaction With CBD
Cannabidiol or CBD has several benefits that can be credited for its rising popularity, however, it can produce severe complications when it interacts with other drugs.
CBD can interact with other drugs to produce either increased or decreased effects of the main drug.
These interactions can have either low, moderate, or severe clinical significance with low interactions not requiring any form of precaution, moderate interactions being avoided unless medically necessary, and severe being avoided at all costs.
Based on the effect of CBD on the main drug, the CBD-drug interactions can be classified into three types:
1. Agonistic Interaction
CBD increases the effect of the drug by exerting the same effects. This is common in drugs that share similar painkilling, sedative, anxiolytic, or anti-inflammatory effects.
2. Antagonistic Interaction
CBD decreases the effect of the drug by either clearing the drug from the system faster or inhibiting its effects. This is common in drugs with effects that are opposite to CBD — such as stimulants, emetics, or low blood pressure medications.
3. Metabolic Competition
CBD blocks or competes with the metabolism of medications in the liver. This can cause the concentrations of both substances to increase in the bloodstream, potentially leading to side effects.
This interaction is most concerning for medications used on a daily basis because it can cause levels to rise to dangerous levels over time.
Key Takeaways: Can CBD and Aspirin be Taken Together?
CBD and Aspirin have similar effects for managing pain and inflammation. There’s some mild risk of interaction between these substances, but only when used in high doses or for long periods of time.
Most people find greater pain relief when using both Aspirin and CBD together.