The CBD-IC Randomized Controlled Trial: Evaluation of Hemp Cannabidiol SuppositoRies for Pain and Urinary SymptOms in INterstitial Cystitis (CHRONIC) (CHRONIC) This study seeks to exploit bladder During sex, the abdominal pain that Interstitial Cystitis generates may be almost unbearable – however, many patients have reported significant improvement in their IC symptoms by using CBD. CBD from cannabis is one of the most practical ways to deal with a chronic condition like IC, and it has been used medicinally for centuries.
The CBD-IC Randomized Controlled Trial: Evaluation of Hemp Cannabidiol SuppositoRies for Pain and Urinary SymptOms in INterstitial Cystitis (CHRONIC) (CHRONIC)
This study seeks to exploit bladder cannabidiol receptors as a therapeutic drug target by conducting a double-masked, placebo-controlled randomized trial evaluating the effects of vaginal hemp cannabidiol (CBD) suppositories on lower urinary tract symptoms (LUTS), pain severity, and sexual function.
|Condition or disease||Intervention/treatment||Phase|
|Interstitial Cystitis Bladder Pain Syndrome||Drug: Cannabidiol vaginal suppository Drug: Placebo vaginal suppository||Phase 1|
Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS) is a chronic inflammatory disease with an insidious course and is detrimental weight to women’s quality of life, sexual function, and general health. IC/BPS affects nearly 1.2 million women in the United States and although there are currently six lines of treatment, they lack high level evidence and sufficient efficacy. New therapies are in high demand. As the cannabis industry gains popularity in medicine, research has revealed prevalent expression of cannabinoid receptors in bladder detrusor muscle and urothelium suggesting a novel drug target for IC/BPS. This study seeks to exploit this target by conducting a double-masked, placebo-controlled randomized trial evaluating the effects of vaginal hemp cannabidiol (CBD) suppositories on lower urinary tract symptoms (LUTS), pain severity, and sexual function. Women with diagnosed IC/BPS will be randomized to treatment with a placebo vaginal suppository or a hemp CBD vaginal suppository. We will monitor changes in their LUTS, pain, and sexual function using validated questionnaires. Our goal is to evaluate whether CBD is an effective, low-risk and less invasive treatment option for IC/BPS. Attainment of this goal would demonstrate a potential novel use for CBD in our Urogynecology patient population.
Best Lube for Interstitial Cystitis
During sex, the abdominal pain that Interstitial Cystitis generates may be almost unbearable. However, many patients have reported significant improvement in their IC symptoms by using CBD. For this reason, this article will discuss the best CBD lube for Interstitial Cystitis.
What Is CBD?
CBD is short for cannabidiol, the second most common active ingredient of cannabis after Tetrahydrocannabinol (THC). Unlike THC, CBD doesn’t cause psychoactive effects.
Marijuana is the name used for strains of cannabis that have more than 0.3% of THC. Hemp, while low in THC, is comparatively high in CBD. We can generally define hemp as being from the Cannabis sativa strain and having a THC content of less than 0.3%.
CBD does not induce the same feelings of ‘highness’ that people experience when they use marijuana. Furthermore, the World Health Organization reports that CBD doesn’t show any evidence of dependence to date. CBD may be present in vaping fluids, capsules, chocolate products, oils, and lubricants CBD lube can help reduce feelings of discomfort and improve your sexual life.
What Is The Best Lube For Interstitial Cystitis?
Sexologist and author Dr. Sadie Allison, and CBD scientist John Renko, B.S.E. created GoLove, a formulated lubricant made specifically for enhanced sexual health and wellness.
GoLove CBD Lube helps relax pelvic floor muscles and reduces any discomfort from inflammation, including discomfort caused by IC. Plus, GoLove creates a full-body calming sensation that helps relieve tension and sexual anxiety so that you can be more at peace during intimate moments.
Why is GoLove such a great lube for Interstitial Cystitis? Since it was created by doctors, GoLove has extra attention to detail when it comes to health.
- GoLove is water-based, ideal for lubrication and friendly with the lining of the vagina, and contains 200mg of organic CBD, a concentration high enough to be safe and effective. GoLove contains no THC.
- GoLove is research-based and naturally manufactured with body-safe ingredients
- GoLove is hypoallergenic, pH-balanced, and latex-safe so that anyone can use it.
- GoLove is lab-certified and dermatologist-tested. You can find the certification here .
Why Does CBD Help Interstitial Cystitis?
Endocannabinoids are molecules made by the body regardless of whether or not we use cannabis. They are essential in regulating processes like appetite and digestion, metabolism, pain, sleep, stress, reproduction, and fertility.
Some hopeful findings say that cannabinoid receptors are present in the lower urinary tract , which means the bladder walls line up with cannabinoid receptors. So, if systemic cannabinoids affect the lower urinary tract, they may become clinically useful.
THC binds to cannabinoid receptors, but CBD doesn’t. This fact leaves scientists somewhat mystified as to how exactly CBD exerts its effects. Still, it might either prevent your own body’s endocannabinoids from being broken down or improve the receptors’ ability to bind to them. It is also possible that CBD attaches to another type of receptor that is still unknown.
Is There Any Risk To Using CBD Lube?
Though CBD can have a few rare side effects like nausea, fatigue, and irritability, the biggest concern is that it is a supplement, and the FDA does not regulate it. There are a few precautions that can help make sure you’re getting a decent product. First, find out where the hemp was grown and whether it was organically grown. Hemp grown organically in the United States is best because there are stringent regulations in place to qualify as an organic product.
Next, look for a company that grows and extracts its hemp and provides test results from a state-certified testing facility either openly or upon request. Check the inactive ingredients as well.
Look for companies with contact information that is easy to find and lists where their hemp comes from and how it’s grown. Try calling and see if you get through or, at the very least, send an email and see if you can interact with a natural person. For Golove, you can get in contact here .
Is CBD Legal?
The legality factor is how much THC is in the CBD; if the product has less than 0.03 percent THC, it can legally be bought online and shipped right to your door.
Legality is a big question since CBD can come from marijuana, which isn’t legal in all states. But at the end of 2015, the FDA lowered its requirements to allow researchers to do more research on CBD. Its legality can also depend on whether the CBD comes from the hemp plant or the marijuana plant. Hemp plant derivatives are legal, but marijuana plant derivatives aren’t legal everywhere. Each of the 50 states in the United States now has unique laws regarding the legal status of CBD.
CBD for Interstitial Cystitis – Does it Help?
Interstitial Cystitis (IC) is a condition that causes long-term pelvic pain. If you have ever had a urinary tract infection (UTI), you understand the distress this bladder condition causes. It tends to affect people in their 30s and 40s and is much more common in women than men.
Still, unlike UTI, which antibiotics can cure, Interstitial Cystitis does not have a cure, and it can have a significant impact on your daily life, physical and emotional health, and relationships. Fortunately, various treatments can help relieve the symptoms.
Things that can help relieve the pain of these symptoms include lifestyle changes. The traditional therapies include dietary modifications, avoiding certain foods or drinks, reducing stress, pelvic floor therapy, and cannabis.
Cannabis is one of the most practical ways to deal with a chronic condition like IC, and it has been used medicinally for centuries. Cannabis-based products, such as CBD oils and CBD lubricants, have positive effects, can help to decrease inflammation, and potentially alleviate pelvic pain.
Does CBD Lube Work For Interstitial Cystitis?
In our body, we can find multiple cannabinoid receptors that endocannabinoids can bind to, including the lower urinary tract; this means that CBD lubricants are helpful treatments for bladder conditions such as Interstitial Cystitis.
In fact, CBD has effects on people diagnosed with many different illnesses and is proven to do more than relieve pain. Still, it also helps improve sleep quality, which potentially reduces the pain throughout the day and in the mornings also helps with inflammations. CBD’s therapeutic effects are numerous, which is why it would work for all the pains and symptoms that Interstitial Cystitis causes.
Unfortunately, the use of CBD for Interstitial Cystitis is only supported by anecdotal evidence. Some hopeful findings say that cannabinoid receptors are present in the lower urinary tract, which means the bladder walls line up with cannabinoid receptors. So, if systemic cannabinoids affect the lower urinary tract, they may become clinically useful.
CBD Dosage For Interstitial Cystitis
To know how much CBD to take for Interstitial Cystitis, there have been studies where the subjects are given between 150mg CBD, 300mg CBD up to 600mg CBD. Results said that the 300mg dose of CBD reduces pelvic pain significantly.
Sexologist and author Dr. Sadie Allison, and CBD scientist John Renko, B.S.E. created GoLove’s CBD lubricant specifically to enhance wellness and sexual health. As a result, it can help relax pelvic floor muscles and reduce any discomfort and inflammation that Interstitial Cystitis may cause. In case you want to learn more about this, you can read our article about the best lube for Interstitial Cystitis .
GoLove CBD Lubricant comes in several sizes, 40ml with 200mg of CBD and 5ml with 25mg of CBD, and these concentrations are high enough to be effective and safe. Besides, anyone can use it as GoLove is water-based, hypoallergenic, latex-safe, and pH-balanced.